19.1.10

Mesothelioma: New treatments for Mesothelioma cancer



by: Hector Milla
There are more treatment possibilities for Mesothelioma cancer than surgery, chemotherapy and radiation therapy: the clinical trials. They offer no only benefits, but also risks that cancer patients should know before taking part in one of these research studies. 
 
The U.S. National Cancer Institute sponsors clinical trials, because Mesothelioma cancer is difficult to control. This research is being performed to find out new treatments and better ways to use the current medical procedures. 
 
Clinical trials are performed before the application of any new treatment in human beings, because doctors should know if the treatment is safe for their patients and effective to fight the disease on the stage level in which is. 
 
Patients with mesothelioma can participate in research programs as a treatment option, because the possibility exists in the United States. People interested in take part in a clinical trial, however, should talk with their doctors before. 
 
There is information about clinical trials in the Cancer Information Service (CIS) of the above mentioned Institute or may call to the toll-free phone number 1–800–4–CANCER to talk to CIS staff who may identify and provide detailed information about specific ongoing clinical trials. 
 
The Web have various information about the subject, such as basic trial information, trial description with a summary and the eligibility criteria, and trial sites and contacts in the U.S. 
 
About the author:
Article written by the staff of mesothelioma -10.com a website edited by Hector Milla, if you want to read more articles about mesothelioma cancer, feel free to visit http://www.mesothelioma-10.com , or http://www.asbestos-10.com you can reprint this article in your website or ezine, always mentioning the author above and keeping a live link. 
 
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13. Asbestos: Cause Of Deadly Mesothelioma

Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestos



by: Kirsten Hawkins
Sarcomatoid Mesothelioma is a quite uncommon type of cancer caused due to asbestos exposure. While it is difficult to diagnose Sarcomatoid Mesothelioma, it hardly responds to any type of therapy. This is the most serious of all asbestos-related diseases. The possibility of finding this type of cancer is on the lips and the larynx. 
 
However, in certain cases it may affect the oral cavity as well. Like all other forms of mesothelioma cancers, this cancer is a fatal disease and hardly responds to any method of treatment. Even though radiation therapy is recommended for the treatment of these cancerous tumors, but some of them may not be radiosensitive and may defy radiation for treatment. 
 
Diagnosis of Sarcomatoid Mesothelioma:
The differentiation of sarcomatoid mesothelioma from other cell tumors by light microscopy is quite difficult. The role of immunohistochemistry is also not well defined in its diagnosis. Since sarcomatoid mesothelioma is not always cytokeratin-negative, the distinction between it and sarcoma is not always possible. In this context, the doctors undertook a study to investigate the utility of diagnostic immunohistochemistry for distinguishing sarcomatoid mesothelioma from its histological mimics, high-grade sarcoma and pulmonary sarcomatoid carcinoma. 
 
For its study, the researchers stained the mesotheliomas with sarcomatoid components. They assessed the intensity and distribution of staining with the help of a semi quantitative scale. Only tumors with unequivocal staining were considered positive for tabulation. Then they compared the immunophenotypic profiles of these tumors with 24 high-grade sarcomas. The sarcomatoid carcinomas were also stained for thyroid transcription factor-1 (TTF-1). 
 
The study showed that Cytokeratin 5/6 stained most of the epithelioids but the sarcomatoids were rarely stained. On the other hand, Calretinin and thrombomodulin each stained 70% of sarcomatoid. All 10 sarcomatoids were negative for TTF-1. This led to the conclusion that a wide immunophenotypic overlap exists among different sarcomatoids. 
 
Cytokeratin and calretinin have the most value in differentiating different sarcomatoids. Clinicopathological data, especially information about the gross appearance of the tumor is quite important for sarcomatoid tumors. Thus, it should be noted and carefully correlated with microscopic and immunohistochemical findings. 
 
About the author:
Kirsten Hawkins is a asbestos and mesothelioma specialist from Nashville, TN. Visit http://www.asbestosblog.org/for information on asbestos reform, mesothelioma lawsuit news, and more. 
 
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